Mouse Dnmt3a N-terminal domain
DNA methyltransferase (DNMT) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3. The DNMT3 family contains two active methyltransferases, DNMT3A & DNMT3B, and one DNMT3-Like protein. DNMT3A is believed to be important in the regulation of specific patterns of DNA methylation, specifically de novo methylation rather than the maintenance of existing methylated sites. The antibody available was purified from rabbit using highly purified native protein as antigen. The dilutions of both the serum and purified antibodies are 1:200. Reactivity was tested for both the serum and purified antibodies via dot blot using corresponding antigens. This antibody against Dnmt3a does not cross react with Dnmt3b.
Publication: Chang et al. Nat Commun. 2011 2:533.