Technology Listings


Antibody to CD44v6, A Cell Marker for Various Cancers and Inflammation

Applications
  • Flow Cytometry
  • ELISA
  • Immunofluorescence
  • Functional Assays
  • Immunoblotting
  • Western Blot
  • Immunoprecipitation
Specificity

Human

Subtype

Mouse Monoclonal

Antigen

CD44v6 (v6 variant-exon containing form of CD44)

Technical Summary

Antibody binding is increased in the epithelium of inflamed intestinal tissue in mice and in humans with inflammatory bowel disease. CD44v6 is a variation of CD44 that is reported as a cell surface marker for various cancers and inflammation. Emory Researchers have created an antibody, GM35 (an interferon gamma-stimulated intestinal epithelial cell), to bind to a carbohydrate antigen on CD44v6.

Compared to currently available antibodies for these antigens, this new antibody has greater affinity and specificity. Due to its high affinity for a ligand implicated as a marker of inflammation and now with an increasingly recognized role in the clearance of inflammatory cells, the GM35 antibody has potential uses as a research, diagnostic, and possibly therapeutic tool.

Publication: Si-Tahar, M., S. Sitaraman, et al. (2001). Cell Physiology 280(3): C423-C432.

Patent Information
Tech ID: 10183
Published: 1/17/2012
Category
Research Tools

Contact
Tom Tachovsky
Senior Licensing Consultant
Emory University
404-727-2211
ttachov@emory.edu

Inventor(s)
Nancy Louis
Charles Parkos
Jennifer Brazil
Sean Colgan

Keywords
Antibody
Oncology
Gastroenterology