- Western Blot
C-elegans SPE-4 protein as well as other presenilin family proteins. No detectable cross reactivity with other proteins by western blot.
Alzheimer's disease is a neurodegenerative disease characterized by progressive cognitive deterioration together with a decline in activity and neuropsychiatric symptoms. In many patients suffering from Alzheimer's disease, mutations in the presenilin proteins are observed. The SPE-4 protein is a presenilin family transmembrane protein found in c-elegans.
These antibodies can be used to specifically detect SPE-4 protein by immunocytochemistry. They have been shown to detect SPE-4 protein in c-elegans as well as human presenilin proteins in humans. These antibodies can also be used for immunoblotting and immunoprecipitation purposes.
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