Technology Listings

AcµRay: A Modular, Point-of-Care Diagnostic Device


A modular system for the detection of biomarkers consisting of a portable diagnostic device, customizable sensors for multiple diagnostic tests, and software to analyze results.

Key Benefits
  • Easy to use system reduces human error in diagnostic testing.
  • Modular design lowers costs by using one diagnostic device for multiple tests.
  • Small size allows for home or field use.
Market Summary

Early detection of disease is often critical for successful treatment outcomes, especially in progressive diseases such as cancer and infections. Although diagnostic tests exist for a large number of medical conditions, these tests are often invasive, time-consuming, expensive, and/or prone to errors. Diagnostic testing often must be performed by highly skilled laboratory technicians, which increases cost and time until diagnosis. Point of Care Testing (POCT) is diagnostic testing that does not require a specialized lab and thereby allows for rapid test results. However widespread adaptation of most diagnostic tests to POCT devices has not occurred, partly because most equipment is designed for a single purpose (blood glucose meter, home pregnancy test), requiring clinics to purchase numerous devices to cover the range of diagnostic tests performed. While these tests are simple to perform individually, each device often has a different sample preparation procedure that must be performed for each test. Having different sample preparation procedures for each diagnostic test a clinic performs increases the time to perform tests, as samples must be prepared separately, and increases the chance of error due to improper sample preparation.

Technical Summary

AcµRay was designed to perform any biomarker diagnostic test using the same procedure and device. This simplicity allows for a single clinic to perform a wide range of diagnostic tests quickly and accurately without the need to learn and maintain numerous testing devices. The AcµRay system consists of a small diagnostic device that can be connected to a computer through a USB port. Diagnostic tests are performed by plugging a sensor into the device, then running a blood sample through the device. The attached computer then analyzes and reports the results of the test. The sensors consist of a small microchip that can be coated with different antibodies that detect biomarkers. Biomarker binding to the antibodies on the chip changes the acoustic signature of the chip, which is then detected by the reader and interpreted by the attached computer. The AcµRay system is designed to provide multiple sensors that detect selected biomarkers for the medical condition of diagnostic interest. By simply unplugging one sensor and plugging in a new one, the AcµRay device can perform a different diagnostic test. The simplicity of connecting sensors and the standardized procedure for all sensors allows for less skilled technicians to use the AcµRay, a necessary feature for a successful point of care device.

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Developmental Stage
  • Prototype has been developed.
  • Proofs of principle studies for the acoustic sensor using a biomarker for mesothelioma have been conducted.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Nationalized PCT - Foreign EP 14737727.9   1/10/2014   1/10/2034
Nationalized PCT - United States United States 14/759,078 1/10/2014    
Tech ID: 12197
Published: 3/31/2014
Medical Device

Rajsekhar Guddneppanavar
Licensing Associate
Emory University

Paul Doetsch
William Hunt
Dong Shin
Carlos Moreno
Georgia Chen