Knockout mouse models for adhesion G protein-coupled receptors B1, brain-specific angiogenesis inhibitor-1 (ADGRB1/BAI1) gene study.
Emory University researchers have developed a knockout mouse model for the ADGRB1/BAI1 gene. These mice were developed through homologous recombination and have LacZ gene knock-in. Mice were backcrossed on C57Bl6 background for over 9 generations. These mice can be used to study the effects of losing BAI1 expression throughout the whole mouse body. They can also be used to study the tissue expression of the BAI1 gene promoter through tracking of LacZ expression. BAI1 has roles in neuroscience, behavior, pathogen phagocytosis, myogenesis, and cancer.
Model is available for license.