- Western Blot
β -secretase (BACE) of mouse, rat, and human origin.
β -secretase (BACE) is an aspartic-acid protease important to the formation of the amyloid-β peptides that form senile plaques in brains of Alzheimer's disease patients. Additionally, it is also involved in the formation of myelin sheaths in the peripheral nervous system. Two sets of monoclonal antibodies have been generated, one targeting the cytoplasmic region of BACE, and a second targeting the lumenal region. These antibodies show no cross reactivity with other secretase enzymes and have been used for immunofluorescence staining, western blotting, and immunoprecipitation applications.
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