Cloning and studying the L-proline transporter.
This invention is the first cDNA clone encoding a L-proline transporter. The
clone makes it possible to perform high-level structural analysis of L-proline
uptake. The clone permits the generation of antibodies capable of specifically
recognizing L-proline in the pathways in which it is expressed. The precise role
of L-proline as a neurotransmitter is the subject of current investigation.
Certain results suggest that L-proline plays a role in interacting with
glutamatenergic neurons, possibly as an inhibitor. In the short term, the cDNA
should prove a valuable tool in elucidating the role of L-proline. As the role
of L-proline is better defined, therapeutic applications for the cDNA are likely