Technology Listings


Ultrafine Oligosaccharide-Coated Iron Oxide Nanoparticles

Application

Ultrafine magnetic iron oxide nanoparticles (IONPs) coated in oligosaccharides for enhanced contrast in magnetic resonance imaging (MRI).

Key Benefits
  • Oligosaccharide coating is biocompatible.
  • Coating leads to increased water solubility and solution stability.
  • Small size promotes a high efficiency contrast enhancement for MRI that can differentiate between tissue and vasculature.
  • Improved clearance compared to IONPs coated in larger polymer-coated iron oxide nanoparticles.
Market Summary

Iron oxide nanoparticles (IONPs) are iron oxide particles with a diameter ranging from 1-100 nm. For many years, IONPs have been explored as potential drug delivery and imaging agents as they display unique and desirable properties compared to larger particles. These include enhanced magnetic properties as well as low toxicity, features that make them good contrast agents to enhance MRIs of tissues. As the use of imaging for disease diagnosis and monitoring increases, the market for MRI contrast agents is expected to grow rapidly, however, currently used MRI contrast agents are slowly excreted, raising concerns about potential toxicity. Some additional challenges that have limited the extensive use of IONPs in imaging are their poor water solubility and low stability under physiological conditions.

Technical Summary

Emory researchers have developed ultrafine (approx. 3 nm) IONPs coated with oligosaccharides (polymerized glucose) that display both enhanced water solubility and increased solution stability. These IONPs are quickly excreted, reducing potential toxicity concerns, and therefore show promise for potential use in the clinic. Additionally, these coated IONPs have an improved T1/T2 ratio significantly better than the current state-of-the-art gadolinium contrast agents like Multihanceâ„¢. This contrast enhancement allows for imaging and differentiation of both liver tissue and the surrounding vasculature; imaging both is not possible with either gadolinium contrast agents or existing IONPs.

Development Stage

Oligosaccharide-coated iron oxide nanoparticles have been used for in vivo contrast-enhanced MRI in mice.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Utility(parent) United States 14/797,775 7/13/2015    
Tech ID: 14032
Published: 4/27/2015
Category
Drug Discovery
Micro and Nanotechnology

Contact
Cliff Michaels
Assistant Director
Emory University
404-727-3890
ccmicha@emory.edu

Inventor(s)
Hui Mao
Jing Huang

Keywords
Imaging