Catecholamine derivatives, methods and compositions effective for the
treatment of obesity and neurological diseases and disorders.
- Catecholamine derivatives for the treatment of metabolic disorders, such
as obesity, have been developed.
- Catecholamine derivatives promote neuroprotection and may be useful in the
prevention and/or treatment of ALS, Parkinson's disease, Alzheimer's disease
and other neurological diseases and disorders.
Neurotrophins are a family of proteins that induce the survival, development
and function of neurons. One such neurotrophin, brain-derived neurotrophic
factor (BDNF), is a natural tyrosine kinase B (TrkB) ligand. BDNF binds to TrkB
increasing neuronal cell survival, differentiation and synaptic plasticity.
Dr. Keqiang Ye has identified catecholamine derivatives that act like BDNF
and activate the TrkB receptor. The compounds and methods could be useful
for neuroprotective therapy, treatment of various neurological diseases, and
treatment or prevention of obesity. For example, Dr. Ye has demonstrated that,
in mouse models of obesity, activation of TrkB receptors reduces appetite and
body weight in a dose-dependent manner.