Technology Listings


Transgenic Human Dopamine Beta-hydroxylase Mouse Model

Applications

Mouse model that utilizes a BAC to express human dopamine beta-hydroxylase in the brain.

Key Benefits
  • In vivo approach to dissect role of single genes in the nervous system.
  • May be used in the study of how human variants of dopamine beta-hydroxylase affect norepinephrine signaling in the brain.
Technical Summary

Dopamine beta-hydroxylase is encoded by the DBH gene and converts dopamine to norepinephrine. These signaling molecules are involved in a variety of processes important in Parkinson disease, drug dependence, and mental illness. Researchers at Emory have developed a mouse model to examine how natural human variants of dopamine beta-hydroxylase affect the signaling molecules dopamine and norepinephrine in the brain.

Patent Information
Tech ID: 15055
Published: 2/9/2016
Category
Research Tools

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
hkim70@emory.edu

Inventor(s)
Joseph Cubells
David Weinshenker

Keywords
Mouse Model