Technology Listings


Thrombomodulin Conjugates

Application

Biologic conjugates that have anti-inflammatory properties and can be used as systemic agents for treatment of blood clots, stroke, heart attack, or other inflammatory/prothrombotic conditions.

Key Benefits
  • Can also be used to coat cells and tissues to enhance their anti-inflammatory properties or can be used to coat devices such as vascular grafts, stents, heart valves, dialysis membranes, membrane oxygenators, catheters, or guide wires to alter surface properties.
  • Has dramatically enhanced water solubility, improved plasma half-life, increased stability, and possibly decreased protein immunogenicity due to addition of poly(ethylene glycol).
Technical Summary

An effective blood-contacting surface is dependent upon the presence of physiologically relevant anti-thrombotic mechanisms that are incorporated into the engineered blood-material interface. Thrombomodulin (TM) is a critical regulator of the protein C pathway, which represents the major anticoagulant mechanism operative in both normal and injured blood vessels under physiologic conditions in vivo. Although TM can be incorporated into engineered blood-contacting surfaces, major drawbacks of using full length TM include loss of stability with time and significant reduction in TM bioactivity as a result of surface coupling methods currently available. Dr. Chaikof and colleagues have developed novel compositions and a method for adding poly(ethylene glycol) to produce improved thrombomodulin derivatives. These TM derivatives can also be conjugated to linear or multifunctional natural or synthetic compounds that contain other anti-inflammatory or anti-thrombotic properties. Use of these TM derivatives in combination with other anti-inflammatory and/or anti-thrombotic agents may improve biocompatibility and reduce host immune response following cell/organ transplantation or implantation of prosthetic devices.

Developmental Stage

Biologic conjugates have been synthesized and described. Conjugates retain full bioactivity.

Publication: Bioconjugate Chem. 2004, 15, 1005-1007.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Nationalized PCT - United States United States 10/598,149 7,833,978 2/22/2005 11/16/2010 2/2/2026
Tech ID: 04027
Published: 2/24/2009
Category
Therapeutics
Medical Device

Contact
Cliff Michaels
Assistant Director
Emory University
404-727-3890
ccmicha@emory.edu

Inventor(s)
Elliot Chaikof
Carolyn Haller
Chrystelle Cazalis

Keywords
Cardiovascular
Biologic