Technology Listings


Therapeutic Target and Methods to Treat Sepsis

Application

The identification of the coinhibitory receptor 2B4 and its ligand CD48 as targets for the treatment of sepsis.

Key Benefits
  • A target for the prevention of mortality during sepsis.
  • Blocking the 2B4 coinhibitory receptor or its ligand, CD48, may reduce mortality during sepsis in humans.
Market Summary

There are approximately 750,000 cases of sepsis annually in the U.S., with up to 370,000 deaths. Currently, there are no approved therapeutics available for the treatment of sepsis if antibiotics and supportive therapy fail. Immune dysregulation can result in immune incompetence, an important mechanism causing mortality during sepsis. Coinhibitory receptors are a class of molecules that can inhibit the survival and function of T cells during an immune response. The blockade of these pathways may represent a potential therapeutic strategy for the treatment of sepsis.

Technical Summary

Recent studies have shown that specific immune dysregulation occurs during sepsis. Emory inventors have found that the coinhibitory receptor 2B4 plays a functional role in contributing to immune incompetence and mortality during sepsis. Initial studies indicate that CD4 T-cells from patients with sepsis have elevated 2B4 expression. The inventors have identified 2B4 as a potential target for immunotherapy in sepsis and propose a method of treatment for sepsis by using an antibody against 2B4 or a 2B4-Ig fusion protein to bind to and inactivate CD48.

Developmental Stage
  • Mouse studies have shown that 2B4 knock out mice have increased survival following induction of sepsis.
  • Humanized anti-2B4 monoclonal antibodies are in development.
Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Utility(parent) United States 15/159,297 5/19/2016    
Tech ID: 14111
Published: 6/24/2016
Category
Therapeutics

Contact
Cale Lennon
Director, Licensing
Emory University
404-712-4758
jlennon@emory.edu

Inventor(s)
Mandy Ford
Craig Coopersmith

Keywords
Immunology/Inflammation
Microbiology/Infectious Diseases