Technology Listings


Surgical Kit for Treating Age-Related Macular Degeneration (AMD)

Application

Instruments for surgical treatment of age-related macular degeneration (AMD).

Key Benefits
  • Surgical procedure provides a less costly, curative alternative to expensive drug therapeutics that usually only prevent or slow disease progression.
  • One time surgical treatment applicable to both wet and dry AMD.
  • Specialized instruments allow for precise manipulation of delicate optic tissue during the surgical procedure.
Technical Summary

AMD is the leading cause of blindness in people over the age of 50. There are two forms of AMD, wet and dry. Both result in deterioration of the retinal tissues and progressive, irreversible blindness. With wet AMD, new blood vessels form resulting in leakage in the diseased area. With dry AMD, more gradual tissue degradation occurs and can result in formation of drusen. Unfortunately, patients with dry AMD, which is the most common form of AMD, are not candidates for currently available drug-based therapies. These drugs are targeted to mechanisms specific to wet AMD. In addition, these therapies are costly, requiring multiple treatments over extended periods of time. Furthermore, drug-based therapies usually only prevent or slow progression of the disease as opposed to restoring lost vision.

Surgical transplantation of an AMD patient's own healthy tissue from outside their central visual field has been shown to restore AMD-related vision loss. Although the feasibility of this approach has been tested successfully in humans, the procedure has not been widely adopted, in part due to surgical trauma and lack of specialized tools to perform the surgery. Dr. Timothy Olsen and colleagues have developed new instruments to facilitate this procedure.  The instruments are designed to support delicate optical tissue during transplantation, thereby protecting tissue integrity and allowing the surgeon to manipulate the optical tissue with ease. The use of these tools to perform this procedure will likely result in improved outcomes, more reproducible surgeries, and reduced surgical trauma.

View our video on this technology.

View our featured innovation.

Review our Breakfast Club PowerPoint

Developmental Stage
  • Instrument prototypes have been developed and are being tested in animals.
  • Animal and human studies support the feasibility of this surgical procedure.
Publications

Joussen et al. (2006) American Journal of Ophthalmology, 142: 17-30.
Joussen et al. (2007) Ophthalmology, 114: 551-560.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Utility(parent) United States 11/502,603 9/8/2006    
Nationalized PCT - Foreign EP 10833971.4   11/24/2010   11/24/2030
Nationalized PCT - United States United States 13/511,690 9,539,082 5/24/2012 1/10/2017 7/15/2031
Continuation United States 15/388,378 12/22/2016    
Tech ID: NCS.04
Published: 6/6/2013
Category
Medical Device

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
hkim70@emory.edu

Inventor(s)
Arthur Erdman
Paul Loftness
Timothy Olsen
David Rosen
Shreyes Melkote
George Koruthu Mathai

Keywords
Sensory Organs/Ophthalmology