Technology Listings


Stent Sheath Technology For Local Drug Delivery Following Angioplasty

Application

Sleeve device around a stent that facilitates local drug delivery in arteries following an angioplasty.

Key Benefits
  • Prevents restenosis and other complications following angioplasty.
  • Controlled release of coated drug (such as anticoagulant) prevents thrombosis, cellular proliferation and scarring in blood vessels.
Technical Summary

Emory Researchers have developed and patented a novel stent technology that has a polymer-coated sheath encompassing it to deliver a drug locally to arterial walls or lumen following percutaneous transluminal coronary angioplasty (PTCA) procedures. The drug-releasing sheath prevents major complications associated with PTCA procedures, such as acute occlusion and restenosis as well as bleeding complications due to systemic anticoagulant administration post angioplasties.

A separate polymer-coated sheath around the stent provides distinct advantages over stents that are directly coated with polymer. The latter are not as effective at preventing thrombosis due to cracking of the polymer during stent expansion, saturation of anticoagulant-binding sites on the stent, and inadequate anticoagulant in the prevention of thrombosis. An external sleeve around the stent provides a greater surface area for drug delivery and minimizes inadequacies that lead to restenosis.

Developmental Stage

Proof-of-principle has been demonstrated in animal models.

Patent Information
Tech ID: 91027
Published: 5/19/2011
Category
Medical Device

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
hkim70@emory.edu

Inventor(s)
Stephen Hanson
Laurence Harker
Spencer King, III
Neal Scott

Keywords
Cardiovascular