Technology Listings


S1112 Anti-SG2NA Monoclonal Antibody

Applications
  • Immunoprecipitation
  • Immunofluorescence
Specificity

Human, mouse, and rat S/G2 nuclear autoantigen (SG2NA) protein

Subtype

Mouse monoclonal

Technical Summary

S/G2 nuclear autoantigen (SG2NA) is a protein of the striatin family expressed in most cells that act as a scaffold to organize a large signaling complex containing kinases, protein phosphatase 2A, and other proteins. It forms heteromers with other striatin-family members (striatin and zinedin) and may be regulated by Ca(2+) given that it has a calmodulin binding domain. The antibody is directed against a peptide from the protein located in the 1st third of the protein. It is capable of immunoprecipitation as well as co-immunoprecipitation with other proteins associated with SG2NA, such as Mob3/phocein and proteinphosphatase 2A. Although not yet tested, it may work in other applications as well. Early experiments suggest that it also works in immunofluorescence. The hybridoma provides a continuous source of monoclonal antibody that will help provide consistency of results and can be used in multiple applications.

Patent Information
Tech ID: 12132
Published: 9/24/2012
Category
Research Tools

Contact
Rajsekhar Guddneppanavar
Licensing Associate
Emory University
RGUDDNE@emory.edu

Inventor(s)
David Pallas

Keywords
Antibody