Technology Listings


Recombinant Respiratory Syncytial Viruses (RSVs) Expressing the G and F Proteins from Various Strains

Application

Recombinant RSV Strains Expressing the G and F Proteins from various geographically distributed RSV strains for use in drug and vaccine screening

Key Benefits
  • Provides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, geographically distinct strains of the virus
  • Expresses the red fluorescent protein mKate2 for easy screening
Market Summary

RSV is a common respiratory virus infecting most of the population at some point during their life and a major cause of lower respiratory tract infections in infants, children, and the elderly. Currently, neither an RSV vaccine nor effective post-infection therapeutic exists. Cases can often result in hospitalization and sometimes death in these populations. RSV vaccine and therapeutic development has faced challenges including high reversion rate and low immunogenicity. There is an urgent need to develop vaccines that provide a long lasting, highly immunogenic response as well as therapeutics that can be given post-infection.

Technology Summary

Researchers at Emory have generated a series of recombinant respiratory syncytial viruses (RSVs) strains to use for vaccine & therapeutic development. Each of these RSVs contains glycoproteins from geographically distinct RSV strains. In each, the G and F genes are replaced with that of other RSV strains from a different geographic region's TX11-56 (Texas), Riyadh 91/2009 (Saudi Arabia), 9320 (Massachusetts), and A1998-12-21 (Tennessee). Each strain also expresses the red fluorescent protein mKate2 and could prove to be useful in further studies in developing therapeutics and vaccines.

Developmental Stage

These recombinant strains have been developed and used for vaccine candidate screening in the lab.

Patent Information
Tech ID: 15026
Published: 3/26/2015
Category
Research Tools
Vaccines
Drug Discovery

Contact
Cliff Michaels
Assistant Director
Emory University
404-727-3890
ccmicha@emory.edu

Inventor(s)
Martin Moore
Anne Hotard (Lopez-Ona)
Christina Rostad
Barney Graham
Syed Moin

Keywords
Respiratory
Microbiology/Infectious Diseases