Technology Listings


Presenillin 1 N-Terminal Monoclonal Antibody

Applications
  • Immunoblotting
  • Immunocytochemistry
Specificity

Human Presenilin-1 N-terminal

Subtypes

Rat monoclonal

Technical Summary

By immunoblotting applications the antibody recognizes a predominant 32 kDa polypeptide in a varitety of samples including PC12 cells transfected with human PS1, complimentary DNA brain biopsy specimens from dementia patients and postmortem Alzheimer's disease patients. PS1 is expressed primarily in neurons, with the protein localizing in the soma and dendritic processes. In contrast, in sporadic Alzheimer's disease cases PS1 immunoreactivity is present in the neuritic component of senile plaques as well as in neurofibrillary tangles. Localization of PS1 immunoreactivity heterogeneous forms of the disease share a common pathophysiology involving PS1 protein.

Publications

Ribaut-Barassin C, et al., Neuroscience. 120 :405-23 (2003).
Lah JJ, et al., J Neurosci. 17: 1971-80 (1997).
Levey AI, et al., Ann Neurol. 41: 742-53 (1997)

Patent Information
Tech ID: RT004
Published: 4/15/2010
Category
Research Tools

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
hkim70@emory.edu

Inventor(s)
Allan Levey

Keywords
Antibody