Technology Listings


Powerful Insecticides Targeting Mitochondrial Complex I

Application

Benzohydrol derived inhibitors of mitochondrial complex I with significant insecticidal activity.

Key Benefits
  • Provides highly potent, complex I inhibitors requiring low amounts for efficacy.
  • Synthesis of the compound is simpler than currently available compounds, reducing the cost of production
Market Summary

The 260 million acres of harvested area in the United States alone relies heavily on the performance and safety of insecticides in order to maximize crop yield while keeping consumers healthy. Currently used insecticides can cause negative side effects in both the environment and humans, including abdominal cramping, nausea and severe coughing. Developing a potent yet otherwise environmentally benign insecticide that is safe to humans at the effective concentration remains an unmet need.

Technology Summary

Collaborators between Emory University and Georgia State University have designed and synthesized potent mitochondrial complex I inhibitors. The newly synthesized inhibitors effectively shut down the mitochondrial complex I which interferes with the normal functions of the electron transport chain. This in effect can damage DNA and specific components of the mitochondria which leads to cell death through the generation of reactive oxygen species. 

Developmental Stage

Compounds have been developed and are available.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
PCT PCT PCT/US2016/030451   5/2/2016   11/1/2017
Tech ID: NCS.13
Published: 5/8/2015
Category
Non-Therapeutics

Contact
Justin Burns
Licensing Associate
Emory University
justin.burns@emory.edu

Inventor(s)
Binghe Wang
Erwin Van Meir
Jalisa Holmes
Stefan Kaluz
Xingyue Ji

Keywords
Agriculture