Benzohydrol derived inhibitors of mitochondrial complex I with significant insecticidal activity.
- Provides highly potent, complex I inhibitors requiring low amounts for efficacy.
- Synthesis of the compound is simpler than currently available compounds, reducing the cost of production
The 260 million acres of harvested area in the United States alone relies heavily on the performance and safety of insecticides in order to maximize crop yield while keeping consumers healthy. Currently used insecticides can cause negative side effects in both the environment and humans, including abdominal cramping, nausea and severe coughing. Developing a potent yet otherwise environmentally benign insecticide that is safe to humans at the effective concentration remains an unmet need.
Collaborators between Emory University and Georgia State University have designed and synthesized potent mitochondrial complex I inhibitors. The newly synthesized inhibitors effectively shut down the mitochondrial complex I which interferes with the normal functions of the electron transport chain. This in effect can damage DNA and specific components of the mitochondria which leads to cell death through the generation of reactive oxygen species.
Compounds have been developed and are available.