Technology Listings


Post-Vitreoretinal Surgery Pain Management

Application

Combination of two generic drugs, an opioid analgesic and corticosteroid, for retrobulbar anesthesia at the start of vitreoretinal surgery to manage post-surgery pain.

Key Benefits
  • Shows decrease in patient reported pain post-surgery compared to current treatment methods.
  • Results in >35% decrease in oral analgesic intake post-surgery by patients.
Market Summary

Vitreoretinal (back of the eye) surgery is performed at rates as high as 26/100,000 people per year. It is more common in aged individuals and therefore surgery rates could climb as the overall population continues to age. Currently in the United States, 1 in 3 can expect to undergo vitreoretinal surgery at some point in their life. While positive surgical outcomes are typically high, as many as 75% of patients complain of severe pain post-surgery, typically within the first 24 hours. This pain leads to the use of oral analgesics to manage pain, which often have a wide range of side effects and increase the cost of recovery. Better pain management methods during surgery could increase patient comfort post-surgery and decrease recovery times.

Technical Summary

Based on reports from ophthalmic surgeries, Emory clinicians showed that combining a corticosteroid anti-inflammatory drug with an opioid analgesic provides longer pain relief after vitreoretinal surgery than current methods. The combination drug treatment decreased average visual analog pain reports during the first 24 hours post-surgery from 3.8 to 1.9, and decreased oral analgesic intake of acetaminophen, hydrocodone and oxycodone by ~35, 75 and 35% respectively.

Developmental Stage

Single-masked clinical pilot study on 60 patients showed decreased patient-reported pain on visual analogue scale 24 hours after surgery. Patients receiving combination treatment also took less oral analgesics post-surgery compared to patients not receiving combination treatment.

    Patent Information
    App Type Country Serial No. Patent No. File Date Issued Date Expire Date
    Nationalized PCT - United States United States 15/024,966 9/25/2014    
    Tech ID: 14011
    Published: 4/29/2014
    Category
    Therapeutics

    Contact
    Hyeon (Sean) Kim
    Licensing Associate
    Emory University
    hkim70@emory.edu

    Inventor(s)
    Timothy Olsen
    Sonia Mehta

    Keywords
    Neuroscience/Pain
    Sensory Organs/Ophthalmology