Use of plant derivatives for the treatment of methicillin-resistant Staphylococcus aureus (MRSA).
- Unique mechanism of action blocks Staphylococcus aureus virulence and pathogenesis without detectable resistance.
- Potential adjuvant therapy for S. aureus, as this solution enhances response to concomitant antibiotic therapy.
Staphylococcus aureus (also referred to as S. aureus or staph) is an abundant, opportunistic pathogen that is the causative agent of numerous infections. Due to its prevalence as a leading cause of healthcare associated infection and its highly multidrug resistant nature, S. aureus is listed among pathogens included under the CDC’s “serious threat” list. The CDC reports over 80,000 invasive methicillin-resistant Staphylococcus aureus (MRSA) infections and 11,285 related deaths occur each year. This presents a huge risk as MRSA is one of the toughest strains of staph to treat, since it is resistant to many commonly used antibiotics. MRSA is a significant health problem that only appears to be increasing in severity with time, as such new treatment strategies are need.
Emory Researchers in Quave Labs have discovered derivatives from the Castanea sativa (Sweet Chestnut) and S. terbinthifolia (Brazilian pepper tree) plant which inhibit MRSA infection. MRSA is known to coordinate many of its virulence and pathogenesis pathways via microbial communication. These plant extracts demonstrate antibacterial properties against MRSA, inhibiting the microbial communication system known to coordinate biofilm formation, virulence, and antibiotic resistance. Application of the derivatives resulted in decreased toxin outputs and lowered hemolytic activity. This indicates that the extracts have the ability to attenuate MRSA illness. Overall, these derivatives have the potential to be used in the treatment against MRSA, as repeat exposure of S. aureus to the extracts did not result in detectable resistance. In addition, it was shown that the extracts attenuated progression of MRSA lesions in animal infection studies.
Mouse model studies have been conducted.
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