Frequency domain near-infrared spectroscopy (fdNIRS) system for non-invasive characterization of blood volume and tissue oxygen saturation at millimeter-scale depths.
- Noninvasive optical method for monitoring tissue oxygen level and blood volume for brain research in small animals.
- Provides portable, cost-effective alternative method to traditional MRI and PET.
- Enables broader range of source-detector measurement, filling the gap in which diffuse theory breaks down.
Brain tissue oxygenation monitoring is critical in brain research and contributes a major revenue segment in the brain research market. Traditional methods of obtaining such data in humans include magnetic resonance imaging (MRI), positron emission tomography (PET), and near-infrared spectroscopy (NIRS). However, these techniques are expensive (MRI/PET), are not portable (MRI/PET), suffer from poor signal-noise ratio when used in small animals (MRI/PET), and are not accurate in small animals (NIRS). To obtain similar information in small animals, invasive techniques that involve resection of scalp and/or skull are required, which is a challenge for experimental design and long-term studies. In contrast, the novel developments with fdNIRS overcomes these limits and provides a portable, noninvasive, and cost-effective alternative.
Emory Researchers have developed a novel means of estimating oxygen saturation and blood volume in small animal brain using frequency domain near-infrared spectroscopy (fdNIRS) in a noninvasive, cost-effective manner. This approach can be applied in small animals with limited sensing area without removing the animal’s scull/scalp. The accuracy of the approach has been verified through in vitro and in vivo experiments.
In vivo study in rats using fdNIRS system for monitoring blood oxygen level has been measured and validated.