Mouse model for the study of the causes and molecular mechanisms that lead to rapid endothelial dysfunction and atherosclerosis.
- There is currently no animal model in which disturbed blood flow can be acutely induced and cause atherosclerosis.
- Allows for studies to understand the links between disturbed flow and atherosclerosis.
- Can be used for genome-wide studies to determine molecular mechanisms underlying flow-dependent regulation of vascular disease.
Atherosclerosis is a condition in which fatty deposits accumulate on artery walls and thicken the artery thus blocking blood flow. Therefore disturbed blood flow and oscillatory shear stress often occurs as a result of atherosclerosis. Dr. Jo has developed a mouse model in which blood flow can be acutely disturbed through partial carotid ligation. This procedure leads to rapid endothelial dysfunction and atherosclerosis in the mouse. Dr. Jo and colleagues have previously used this mouse model to characterize partial carotid ligation as a model of disturbed flow with additional characteristics of low and oscillatory wall shear stress. The model can be used for genome, mechanism, and drug development studies.
Publication: Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1535-43