Technology Listings


Mouse Active Tet1 Catalytic Domain

Application

Active mouse Tet1 catalytic domain.

Technical Summary

Tet1 is a member of a conserved mammalian-specific family of TET (ten-eleven translocation) proteins. The activity of Tet1 converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. TET1 is fused to the MLL (myeloid/lymphoid or mixed-lineage leukemia) protein, a histone methyltransferase, in a subset of acute myeloid leukemia patients.

Developmental Stage

Isolated, purified, and available for licensing.

Publication: Hashimoto et al. Nucleic Acids Res 40:4841-4849. (2012)

Patent Information
Tech ID: 11061
Published: 6/14/2013
Category
Research Tools

Contact
Rajsekhar Guddneppanavar
Licensing Associate
Emory University
RGUDDNE@emory.edu

Inventor(s)
Xiaodong Cheng
Anup Upadhyay

Keywords
Enzyme/Protein
Oncology