Technology Listings


Monoclonal Antibody for High-Affinity Choline Transporter

Application
  • Immunocytochemistry
  • Western Blot
  • Immunoprecipitation
Specificity

Human, rat & mouse high-affinity choline transporter (CHT). No detectable cross reactivity with other proteins by western blot.

Subtype

Mouse IgG1 (monoclonal)

Technical Summary

Acetylcholine functions as a neurotransmitter in both the central and peripheral nervous systems of all vertebrates, and is the principle neurotransmitter used at the neuromuscular junction. Presynaptic synthesis of this vital neurotransmitter requires a supply of choline, which neurons acquire through high-affinity choline transporters (CHTs).

This monoclonal antibody can be used to detect the high-affinity choline transporter in mouse, rat, and human samples by both immunoblotting and immunocytochemistry. It has been shown to label the high-affinity CHT across a host of brain regions as well as in the periphery. Additionally, this antibody can be used for applications employing immunoprecipitation.

Publication: Ferguson et al., J Neurosci, 2003. 23:9697-9703.

Patent Information
Tech ID: 04038
Published: 3/26/2009
Category
Research Tools

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
hkim70@emory.edu

Inventor(s)
Allan Levey
Randy Blakely
Craig Heilman

Keywords
Antibody