- Western blot
- Flow cytometry
- Binds domain 1 of SIRP alpha and SIRP beta.
- Produced in mouse
Signal regulatory proteins (SIRP) are a family of glycoproteins that regulate innate immune functions including leukocyte migration and chemotaxis. In humans, SIRPS are expressed in dendritic cells, monocytes, ganulocytes, neutrophils, and bone marrow progenitor cells. The SIRP family can be further distinguished into two subtypes: SIRP alpha, which possesses a cytoplasmic domain, and SIRP beta, which lacks the cytoplasmic domain.
SIRP alpha was the first to be purified and characterized. SIRP alpha has also been suggested to play a role in platelet homeostasis, tumor suppression, cellular immunity and inflammation.
The anti-SIRP alpha antibody, Clone SAF10.1, can be used to specifically detect SIRP alpha in a wide variety of tissues and cell types. Publication:
Journal of Immunology 179, 7741-7750 (2007)