Technology Listings


Monoclonal AH12.2 Desmoglein-2 Antibodies

Applications
  • Immunocytochemistry
  • Western Blot
  • Immunoprecipitation
Specificity

Human Desmoglein-2 (Dsg2) protein. No detectable cross reactivity with other proteins by western blot.

Subtype

Mouse Monoclonal

Technical Summary

Desmogleins are a family of cadherin proteins that play an important role in the formation of desmosomes, cell-to-cell adhesions, often found in both simple and squamous epithelium. These adhesions are important to ensuring tissue integrity and regulation of paracellular movement of solutes, as well as restricting access of luminal pathogens to underlying tissue compartments.

The monoclonal antibody detailed here, AH12.2, has been developed to detect human desmoglein-2 (Dsg2) and a truncated version of the protein tDsg2, by recognizing an intracellular epitope of the protein. In addition to immunocytochemistry and immunoblotting, these antibodies can also be used for applications involving immunoprecipitation.

Patent Information
Tech ID: 07039
Published: 2/24/2009
Category
Research Tools

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
hkim70@emory.edu

Inventor(s)
Asma Nusrat

Keywords
Antibody