- Western Blot
Human Desmoglein-2 (Dsg2) protein. No detectable cross reactivity with other proteins by western blot.
Desmogleins are a family of cadherin proteins that play an important role in the formation of desmosomes, cell-to-cell adhesions, often found in both simple and squamous epithelium. These adhesions are important to ensuring tissue integrity and regulation of paracellular movement of solutes, as well as restricting access of luminal pathogens to underlying tissue compartments.
The monoclonal antibody detailed here, AH12.2, has been developed to detect human desmoglein-2 (Dsg2) and a truncated version of the protein tDsg2, by recognizing an intracellular epitope of the protein. In addition to immunocytochemistry and immunoblotting, these antibodies can also be used for applications involving immunoprecipitation.