Technology Listings


Human Lung Microvascular Endothelial Cell Line

Application

Human lung microvascular cell line (HuLEC-1).

Technical Summary

Emory and CDC researchers have isolated human lung microvascular cells (HuLEC) and derived the first immortalized human microvascular endothelial cell line of dermal origin. The immortalized cell line (HuLEC-1) maintains microvascular endothelial cell characteristics, including formation of tubules in vitro and the expression of low density lipoprotein (LDL) and von Willebrand’s Factor. These cells show endogenous expression of vascular cell adhesion molecule, expression of E-selectin following TNF-alpha stimulation, and adherence of M. tuberculosis to the cell line. This cell line can be used to study the role of this molecule in a variety of pathological conditions, including allograft rejection, atherosclerosis, primary pulmonary hypertension, and various inflammatory and infectious disorders of the lung and other organs.

Publication: Ades EW, et al. (1992) J. Invest. Dermatol. 99:683-690.

Patent Information
Tech ID: 95034
Published: 2/14/2013
Category
Research Tools

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
hkim70@emory.edu

Inventor(s)
E. Clinton Lawrence
Phyllis Waite-Reese
Edwin Ades

Keywords
Cardiovascular
Immunology/Inflammation
Microbiology/Infectious Diseases
Cell Line
Respiratory