Technology Listings


Human Junctional Adhesion Molecule (JAM-A) Mouse Monoclonal Antibodies

Application
  • Western blot
  • Immunoprecipitation
  • Immunocytochemistry
Specificity

Human junctional adhesion molecule (JAM-A). No detectable cross reactivity to other proteins by Western blot.

Subtype

Mouse IgG1

Technical Summary

Junctional adhesion molecule A (JAM-A) is a transmembrane structural component of intercellular junctions implicated in the regulation of platelet aggregation, cellular adhesion, leukocyte transmigration/inflammation, and in the regulation of paracellular permeability at the level of epithelial and endothelial tight junctions. These monoclonal antibodies (J3F.1, J4F.1, J10.4, and 1H2A9) can be used to specifically detect human JAM-A by immunoblotting or immunocytochemistry. These JAM-A mAbs have been shown to label epithelial cells from intestine, lung, and kidney, prominently in the region of tight junctions and also along lateral cell membranes below the tight junctions.

Publications

Mandell KJ, et al. J Biol Chem. 2005 Mar 25;280 (12):11665-74
Ivanov AI, et al. Mol Biol Cell. 2004 Jan;15(1):176-88
Naik MU, et al. Blood. 2003 Sep 15;102(6):2108-14
Shaw SK, et al. Am J Pathol. 2001 Dec;159(6):2281-91
br 9;104 Feb 2001 al.Cell. et ES,>Liu Y, et al. J Cell Sci. 2000 Jul;113 (13):2363-74

Patent Information
Tech ID: 06097
Published: 3/26/2009
Category
Research Tools

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
hkim70@emory.edu

Inventor(s)
Charles Parkos

Keywords
Antibody