A device for the local delivery of a drug.
One of the most complex and difficult problems that has plagued the medical profession and pharmaceutical industry for decades is the problem of achieving a therapeutic concentration of a drug locally at a target site within the body without producing unwanted systemic side effects. Parenteral or oral therapy of substances directed at treating disease in a particular internal organ must often be given in amounts dependent upon achieving critical systemic blood levels that can produce devastating side effects at other areas in the body. A prime example of a situation where local therapy is needed with drugs that also produce unwanted systemic side effects is the prevention of complications following the placement of a cardiovascular prosthetic device such as a prosthetic vascular graft, patch, or stent used to repair a damaged vessel.
This invention relates to a device for the local delivery of a substance into a natural tissue conduit to a predetermined site, e.g., a blood vessel, and to methods of therapy utilizing the device. In particular, the invention relates to local delivery of a drug into the boundary layer of fluid flowing through a natural tissue conduit, thereby reducing the amount of drug needed to achieve a therapeutic concentration at a predetermined site.