Technology Listings

Curcumin Analogs with Antitumor and Antiangiogenic Properties


Compounds that block tumor angiogenesis and growth.

Technical Summary

This invention describes a group of compounds that block tumor angiogenesis and growth without exhibiting a high level of toxicity with regard to normal vascular endothelial cells. The anti-angiogenic and anti-tumor compounds of this invention can be useful in the treatment of any condition benefiting from angiogenesis inhibition, such as cancer and chronic inflammation. In addition, the analogs may be useful for therapy of restenosis that occurs following angioplasty and stent deployment, diabetic retinopathy and other diseases that are caused by aberrant growth of the blood vessels. We anticipate receiving broad patent coverage to pharmaceutical compositions and methods for treatment of cancer, inflammation, and related disorders.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Nationalized PCT - Foreign Canada 2,393,440   12/4/2000    
Continuation United States 10/690,462 7,371,766 12/4/2000 5/13/2008  
Continuation United States 12/055,068 7,842,705 12/4/2000 11/30/2010  
Tech ID: 99026
Published: 3/26/2009

Justin Burns
Licensing Associate
Emory University

James Snyder
Mamoru Shoji
Dennis Liotta
Eva Ferst
Brian Adams
Matthew Davis

Small Molecule