Pharmaceutical compositions containing glutathione and glutathione disulfide for the prevention and treatment of influenza.
- Glutathione and glutathione disulfide compositions can be applied directly to the epithelia.
- Can be delivered through inexpensive and practical delivery methods, such as lozenges, oral rinses, and nasal sprays.
- Acts without interfering with the body's natural elimination of infected cells.
- May be effective on multiple influenza strains due to its method of action.
The glutathione and glutathione disulfide compositions used in this technology inhibit the production of infectious virus particles likely by interrupting the protease cleavage of viral hemagglutinin after the viral particles are released. By preventing extracellular activation of the virus, these compositions do not interfere with intracellular processes, allowing apoptosis of infected cells to proceed normally. Because the compositions work extracellularly, they can be delivered directly without the use of injections. Finally, this technology, by acting directly on the virus rather than conferring immunity to specific strains, may act to prevent and treat a broader range of strains than traditional immunization techniques.
This technology has been observed to protect against virus production in human small airway endothelial cells.