Technology Listings


C5D5 Monoclonal Antibody Against Human CD47

Applications
  • Flow Cytometry
  • Immunofluorescence
  • Functional Inhibition
  • Immunoprecipitation
Specificity

Human

Subtype

Mouse Monoclonal

Antigen

CD47

Technical Summary

Transepithelial migration of neutrophils (PMN) is a defining characteristic of active inflammatory states of mucosal surfaces. Little is known about the molecular interactions between PMN and columnar epithelia during transepithelial migration. Emory researchers have developed a monoclonal antibody, C5/D5 IgG, raised against integrin associated proteins (CD47). The antibody is capable of inhibiting PMN migration across polarized monolayers of the human intestinal epithelial cell line T84 in a bidirectional fashion.

Publication: Parkos, C. A., S. P. Colgan, et al. (1996). The Journal of Cell Biology 132(3): 437-450.

Patent Information
Tech ID: 10182
Published: 10/6/2011
Category
Research Tools

Contact
Hyeon (Sean) Kim
Licensing Associate
Emory University
hkim70@emory.edu

Inventor(s)
Charles Parkos

Keywords
Antibody
Immunology/Inflammation