Technology Listings


Antibody That Reacts with Inositol Triphosphate (IP3) Receptor-binding Protein (IRBIT)

Applications
  • Western Blot
  • Immunoprecipitation
Specificity

Human

Subtype

Rabbit Polyclonal

Technical Summary

Calcium is responsible for regulating various cellular processes. The elevation of intracellular calcium regulates the activity of Na+/H+ exchanger 3 (NHE3). Emory inventors have identified a polyclonal antibody which cross reacts with inositol triphosphate (IP3) receptor-binding protein (IRBIT). IRBIT is released with IP3, binds NHE3 and activates NHE3 activity in response to calcium. The interaction of IRBIT is necessary for the stimulation of NHE3 activity.

Publication: He, P., et al. (2008). J. Biol. Chem. 283 (48):33544-33553

Patent Information
Tech ID: 15216
Published: 10/26/2015
Category
Research Tools

Contact
Justin Burns
Licensing Associate
Emory University
justin.burns@emory.edu

Inventor(s)
Changhyon Yun

Keywords
Antibody