DNA methyltransferases that are S-adenosyl methionine (AdoMet)-dependent.
- Have distinctly different domains compared to other methyltransferases.
- Have active site residues and peptide binding channels.
These AdoMet-dependent DNA methyltransferases have been isolated, purified, and characterized. Some of the domains of these methyltransferases bear no structural similarity to other AdoMet-dependent methyltransferases available. Their structures suggest a mechanism for the methylation reaction and provides structural basis for functional characterization of each methyltransferase family and the domains within these enzymes.
Methyltransferases are available for licensing.
Zhang et al. EMBO J. 19:3509-3519. (2000)
Zhang & Cheng. Structure. 11:509-520. (2003)
Zhang et al. Cell. 111:117-127. (2002)
Sawada et al. J Biol Chem. 279:43296-43306. (2004)
Qiu et al. Nature Struct Biol. 9:217-224. (2002)