Technology Listings


AdoMet-Dependent Methyltransferases

Application

DNA methyltransferases that are S-adenosyl methionine (AdoMet)-dependent.

Key Benefits
  • Have distinctly different domains compared to other methyltransferases.
  • Have active site residues and peptide binding channels.
Technical Summary

These AdoMet-dependent DNA methyltransferases have been isolated, purified, and characterized. Some of the domains of these methyltransferases bear no structural similarity to other AdoMet-dependent methyltransferases available. Their structures suggest a mechanism for the methylation reaction and provides structural basis for functional characterization of each methyltransferase family and the domains within these enzymes.

Developmental Stage

Methyltransferases are available for licensing.

Publications

Zhang et al. EMBO J. 19:3509-3519. (2000)
Zhang & Cheng. Structure. 11:509-520. (2003)
Zhang et al. Cell. 111:117-127. (2002)
Sawada et al. J Biol Chem. 279:43296-43306. (2004)
Qiu et al. Nature Struct Biol. 9:217-224. (2002)

Patent Information
Tech ID: 05073
Published: 6/14/2013
Category
Drug Discovery
Research Tools

Contact
Rajsekhar Guddneppanavar
Licensing Associate
Emory University
RGUDDNE@emory.edu

Inventor(s)
Xiaodong Cheng
Xing Zhang

Keywords
Enzyme/Protein