Mouse Ahi1 isoforms
A number of neurological disorders are associated with genes that regulate neurogenesis and neural differentiation. One such gene encodes the Ableson helper integration site 1 (Ahi1) protein, and is required for proper formation of the cerebellum and brainstem. A role for Ahi1 has been suggested in common disorders that affect cognition and behavior, including Joubert syndrome and Huntington's disease, as well as autism and schizophrenia spectral disorders. By generating polyclonal antibodies against mouse Ahi1, Dr. Li's group has shown that Ahi1 plays a critical role in neuronal interactions through the regulation of neurotrophic factors.
These antibodies can be used to specifically detect mouse Ahi1 by immunoblotting. They are capable of detecting Ahi1 in mouse brain tissue and transfected cell lines. These antibodies can also be used to identify potential Ahi1-interacting proteins through immunoprecipitation.
Publication: Sheng, G et al. J Clin Invest, 2008. 118: 2785-95.