Technology Listings

A Method and Device for the Transdermal Delivery of Lithium


Lithiderm patch for transdermal lithium delivery.

Key Benefits
  • Minimizes need for routine blood concentration monitoring.
  • Inexpensive, effective method for lithium delivery.
Technical Summary

Lithium is a successful treatment for mania, bipolar disorder, and other psychiatric disorders and, over the past 50 years, has remained the first-line therapy for mood stabilization. Tolerability and compliance issues, however, are a concern for one-third or more of patients. Contraindications are related to pharmacodynamic dosing complications following conventional oral administration. Thus, effective control and improved compliance could be achieved with fewer side effects if lithium could be more effectively delivered. The present technology describes a transdermal method for continuous delivery of lithium. It avoids the spikes and troughs linked to toxicity and ineffective dosing, respectively. This invention minimizes the need for routine blood testing and decreases the total daily dosing required for effective symptomatic control. Thus, the present technology represents an inexpensive and more effective way to treat affective disorders and may reduce the well-established medical-legal liabilities associated with non-compliance.

Developmental Stage

The transdermal delivery of small ions has been studied clinically and proven to be efficacious.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Nationalized PCT - United States United States 09/529,248 6,375,990 10/9/1998 4/23/2002 10/9/2018
Tech ID: 97055
Published: 2/24/2009
Medical Device

Cliff Michaels
Assistant Director
Emory University

Clinton Kilts
Charles Nemeroff