Lithiderm patch for transdermal lithium delivery.
- Minimizes need for routine blood concentration monitoring.
- Inexpensive, effective method for lithium delivery.
Lithium is a successful treatment for mania, bipolar disorder, and other psychiatric disorders and, over the past 50 years, has remained the first-line therapy for mood stabilization. Tolerability and compliance issues, however, are a concern for one-third or more of patients. Contraindications are related to pharmacodynamic dosing complications following conventional oral administration. Thus, effective control and improved compliance could be achieved with fewer side effects if lithium could be more effectively delivered. The present technology describes a transdermal method for continuous delivery of lithium. It avoids the spikes and troughs linked to toxicity and ineffective dosing, respectively. This invention minimizes the need for routine blood testing and decreases the total daily dosing required for effective symptomatic control. Thus, the present technology represents an inexpensive and more effective way to treat affective disorders and may reduce the well-established medical-legal liabilities associated with non-compliance.
The transdermal delivery of small ions has been studied clinically and proven to be efficacious.