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HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Application
Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages.
Key Benefits
Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi.
Relatively low regulatory risk because many...
Published: 4/23/2024
Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Hyunsuk Shim
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Reprogramming of Fibroblasts toward a Three-Dimensional Vascularized Cardiomimetic Tissue (CMT)
Application
Fibroblasts reprogrammed into tissue-like patch including functional cardiomyocyte, endothelial, smooth muscle and pericyte cells for treatment of cardiac diseases.
Key Benefits
Enables simultaneous reprogramming of multi-lineage cells including cardiomyocytes and endothelial cells
Increases expression of cardioprotective paracrine...
Published: 4/23/2024
Contributor(s): Young-Sup Yoon, Jaeyeaon Cho
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Nanomatrix Gel to Improve Cardiac Repair
ApplicationInjectable, self-assembling, nanomatrix gel for the enhancing cell retention and function in tissue for use in cell based therapy. Key BenefitsIncreases implanted cell retention and enhances cardiac repair after stem cell treatment. Mimics the extracellular matrix to encourage stem cell engraftment.Market SummaryNearly 1 million Americans...
Published: 4/23/2024
Contributor(s): Young-Sup Yoon, Kiwon Ban, Ho-Wook Jun
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Purification of Specific Cell Types from Stem Cells via Fluorescent Probes
Application
Dual-labeled antisense oligonucleotide probes for fluorescent activated cell sorting (FACS) of pluripotent stem cells.
Key Benefits
Allows for the purification of a homogeneous cell population compared to currently available techniques which can only produce heterogeneous mixtures.
Binds intracellular RNA using standard delivery techniques...
Published: 4/8/2024
Contributor(s): Young-Sup Yoon, Kiwon Ban, Brian Wile, Gang Bao
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Functional Restoration of Diabetic Bone Marrow-Derived Cells
Application
Methods for restoration of diabetic bone marrow cell function for cell based therapy, using pre-existing molecules and their derivatives.
Key Benefits
Ability to "reactivate" diabetic bone marrow-derived stem or progenitor cells which also include peripheral blood cells such as endothelial progenitor cells.
Cells are more...
Published: 4/23/2024
Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han
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Chemically Induced Pluripotent Stem (CiPS) Cells
Application
Generation of pluripotent stem cells from adult somatic cells for medical use.
Key Benefits
No exogenous genetic manipulations, which minimize oncogenic effects, were observed in current methods.
Peripheral blood can be used as a source of parent cell instead of fibroblasts or keratinocytes.
Market Summary
The economic and psychological...
Published: 4/23/2024
Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Xiaodong Cheng, Antonello Mai
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Device and Kit Isolate Vasculogenic Cells from Blood
Application
A device and kit for isolating therapeutic quantities of vasculgenic cells from blood that acts as an autologous adult stem cell therapy for the treatment of limb ischemia, ischemic heart disease, and other vascular-related disorders.
Key Benefits
Reduces complexity and expense of current autologous stem cell therapies.
Cells can be...
Published: 4/23/2024
Contributor(s): Young-Sup Yoon, Hyun-Jai Cho
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