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Quinazolin-4(3H)-one Derivatives as NOX-2 Inhibitors: Composition of Matter, Methods of Preparation and Their Use
Application
Quinazolin-4(3H)-one derivatives as selective NOX-2 inhibitors to prevent oxidative damage.
Key Benefits
Small molecule NOX-2 specific inhibitor.
Prevents excessive reactive oxygen species (ROS) generation rather than removing them.
Selective NOX-2 inhibition offers significant advantages to development of an effective therapy against...
Published: 4/8/2024
Contributor(s): Thota Ganesh, Radhika Amaradhi, Jacek Zielonka
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Alexidine and Analogs to Treat Lung Cancer
Application
Small molecule therapeutic specifically targeting invasive cancer cells for treatment of lung cancer.
Key Benefits
Inhibits cancer cell invasion.
Utilizes a novel mechanism of action.
Market Summary
One of the main barriers in developing new treatment strategies is the vast diversity between and within cancers. The cells within...
Published: 4/8/2024
Contributor(s): Adam Marcus, Jessica Konen, Rachel Commander, Jamie Arnst, Thota Ganesh
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Novel Inhibitors of NOX2/ROS
Applications
Novel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD).
Key Benefits
NOX2/ROS inhibitors have potential for use in a wide variety of clinical indications.
Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases.
Technical...
Published: 7/28/2023
Contributor(s): Thota Ganesh, John David Lambeth, Susan Smith, Aiming Sun
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