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Small Molecule Inhibitors of Mcl-1 as Anti-Cancer Agent
ApplicationMyeloid cell leukemia 1 (Mcl-1) inhibitor to enhance DNA replication stress sensitivity for cancer therapy.Key BenefitsInhibits DNA repair in cancer cells.Used in combination with existing cancer therapy.Market SummaryChemoresistance occurs when cancer cells develop resistance to chemotherapy drugs, and appearance of chemoresistance grea...
Published: 6/24/2019       Inventor(s): Xingming Deng, Guo Chen, Abu Syed Md Anisuzzaman
Small Molecule Inhibitors of NADPH Oxidase 4 (NOX4) Signaling
ApplicationSmall molecule inhibitors of NOX4 signaling with a wide array of therapeutic potential.Key BenefitsSmall molecule inhibitors of NOX4 signaling.Low cytotoxicity.Market SummaryThe NADPH oxidase 4 (NOX4) has gained considerable and growing attention during the past years because of its potential key involvement in a variety of diseases, som...
Published: 5/13/2019       Inventor(s): Bernard Lassegue, Kathy Griendling, David Brown, Qian Xu, Osman Guner, J. Phillip Bowen, Amol Kulkarni, E. Blake Watkins
Glycolysis Inhibitors as Potential Cancer Therapeutics
ApplicationA new potential anti-cancer agent that inhibits the glycolytic enzyme PGAM1 and thereby tumor growth.Key BenefitsTargets tumor metabolism by inhibiting glycolytic enzyme and turning off tumor metabolism.Inhibition of glycolytic enzyme (PGAM1) by these inhibitors leads to significant reduction in tumor growth.Market SummaryTreating cancer...
Published: 4/23/2019       Inventor(s): Jing Chen, Taro Hitosugi, Sumin Kang
Alexidine and Analogs to Treat Lung Cancer
ApplicationSmall molecule therapeutic specifically targeting invasive cancer cells for treatment of lung cancer.Key BenefitsInhibits cancer cell invasion.Utilizes a novel mechanism of action.Market SummaryLung cancer is the second most prevalent type of cancer, causing more than 150,000 deaths in the United States per year. One of the main barriers...
Published: 4/12/2019       Inventor(s): Adam Marcus, Jessica Konen, Rachel Commander, Jamie Arnst, Thota Ganesh
Liver Receptor Homolog 1 (LRH-1) Agonist for the Treatment of Type 2 Diabetes and Inflammatory Bowel Disease
ApplicationSmall molecule agonist that changes the expression of LRH-1 genes involved with lipid metabolism and inflammation.Key BenefitsLess toxic and more potent molecule compared to known LRH-1 agonists.More soluble compound that improves its pharmacokinetics (PK).Market SummaryLiver receptor homolog 1 (LRH-1) is a nuclear hormone receptor that ...
Published: 3/26/2019       Inventor(s): Eric Ortlund, Suzanne Mays, Nathan Jui, Autumn Flynn, Michael Dugan
PLK1 Inhibitors for the Diagnosis and Treatment of Small Cell Lung Carcinoma (SCLC)
ApplicationPolo Like Kinase 1 (PLK1) inhibitor as a potent treatment strategy for SCLC patients with a specific TP53 mutation.Key BenefitsA personalized cell therapy for recurrent SCLC cases.Higher efficiency in TP53 mediated PLK1 inhibition to control carcinoma.PLK1, a predictive biomarker for SCLC diagnosis.Market SummaryLung cancer is the most c...
Published: 12/6/2018       Inventor(s): Taofeek Owonikoko
Cancer Cell Metabolism Inhibitors for Targeted Therapies
ApplicationGlutamate dehydrogenase (GDH1) inhibitors targeting cancer cell metabolic pathways.Key BenefitsTargets tricarboxylic acid (TCA) cycle/mitochondrial metabolism utilized by several cancer cell types for cell growth and survival.Reduces cell proliferation and viability in several tumor derived cell lines as well as in xenograft tumor models...
Published: 12/6/2018       Inventor(s): Sumin Kang, Jing Chen, Lingtao Jin
Small Molecules for Development of Cardiac Chamber-Specific Myocytes
ApplicationSmall molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting.Key BenefitsProduces highly-enriched, subtype-specific populations of cardiac myocytes.Eliminates need for cell-sorting.Does not require transgenic changes to the human stem cells.Market Summ...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Pengcheng Han
Biological Pacemakers as Alternatives/Adjuncts to Electronic Pacing Devices
ApplicationNon-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm.Key BenefitsMinimally invasive procedure provides cardiac pacing without device implant.Restores natural heart rhythm.Eliminates or reduces significant complications such as repeat surgeries ...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Jun Li
Small Molecules for Treating Multiple Myeloma
ApplicationSmall molecule inhibitor of glucose transporter isoform 4 (GLUT4) for the treatment of cancer.Key BenefitsInhibits glucose uptake in myeloma cells, reducing cell proliferation.Sensitizes multiple myeloma cells to standard therapeutics.Market SummaryEach year in the United States almost 30,000 new cases of multiple myeloma (MM) are diagno...
Published: 4/17/2018       Inventor(s): Malathy (mala) Shanmugam, Gary Schiltz, Rama Mishra, Paul Hruz
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