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Growth Factor as a Treatment for Obesity
Applications
Therapeutic use of Glial Cell Line-Derived Neurotrophic Factor (GDNF) to treat obesity.
Potential drug target for further therapeutic development.
Key Benefits
Growth Factor expression in the brain causes a reduction in high fat diet-induced obesity.
Fat level reduction has been shown in both mouse and human cells.
Reducing...
Published: 4/23/2024
Contributor(s): Shanthi Srinivasan
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Mouse Enteric Neuronal Cell Line
Application
Fetal and postnatal enteric neuronal cell lines for use in studying the enteric nervous system.
Technical Summary
We have developed fetal (IM-FEN) and postnatal (IM-PEN) enteric neuronal cell lines with features similar to primary enteric neurons. The IM-FEN and IM-PEN have been passaged 40 times since their isolation and have shown no...
Published: 4/23/2024
Contributor(s): Shanthi Srinivasan
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Neurotrophic Factor as Therapeutic for Diabetes
Application
The use of Glial Cell-derived Neurotrophic Factor (GDNF) or its mimics as a potential therapeutic for diabetes mellitus type 1 (IDDM).
Key Benefits
GDNF enhances pancreatic β-cell growth and survival in vitro and in vivo.
GDNF transgenic mice have lower blood glucose levels and are more resistant to developing diabetes compared...
Published: 4/23/2024
Contributor(s): Shanthi Srinivasan
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