6 Results

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Small Molecules to Promote Bone Growth Application Small molecule sclerostin-inhibitors to enhance the canonical Wnt pathways and promote BMP-induced osteoblast differentiation. Key Benefits Repurposing opportunities of FDA approved drugs. Lower cost compared to currently available monoclonal antibody or recombinant protein therapies. Stable compounds with established safety profiles... Published: 4/23/2024       Contributor(s): Scott Boden, Steven Presciutti, Sreedhara Sangadala

Repurposed Small Molecules that Promote Osteogenesis Application Repurposed small molecules for use as a bone forming therapeutic during treatment of diseases requiring local bone formation such as fracture repair, spinal fusion, and large segmental bone defects. Key Benefits Current treatments require high concentrations of bone morphogenetic protein (BMP) which results in high costs, adverse side... Published: 7/28/2023       Contributor(s): Scott Boden, Sreedhara Sangadala

Small Molecule Therapeutic for Regeneration of Cartilage ApplicationSmall molecule therapeutic that can be delivered locally to enhance TGF-beta activity and promote cartilage growth.Key BenefitsIncreases production of protease inhibitors, simultaneously stimulating production and blocking degradation of extracellular matrix (ECM). Potentially reduces or eliminates need for joint replacements by regenerating... Published: 4/23/2024       Contributor(s): Scott Boden, Sreedhara Sangadala

JabI Inhibitor: Bone Forming Small Molecule for Use in Spinal Fusion Devices Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Small molecule therapeutics... Published: 4/23/2024       Contributor(s): Scott Boden, Sreedhara Sangadala

Noggin Inhibitor: Bone Forming Small Molecule for Use in Spinal Fusion Devices Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Small molecule therapeutics... Published: 4/23/2024       Contributor(s): Scott Boden, Sreedhara Sangadala

Novel Bone Forming Compound for Use in Spinal Fusion Device Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Commercially available small... Published: 4/23/2024       Contributor(s): Scott Boden, Sreedhara Sangadala