Small Molecule Potentiators of NMDA Receptors for Treating Neurological Conditions
Application
Multiple series of small molecules that selectivity potentiate NMDA receptors composed of specific subunits including GluN2B, GluN2C, GluN2B/GluN2C/GluN2D, and GluN2C/GluN2D.
Key Benefits
Small molecule potentiators enhance endogenous signals without exogenous activation.
Subunit selectivity allows targeting of specific subtypes of...
Published: 7/28/2023
Contributor(s): Dennis Liotta, Ethel Garnier-Amblard, Gabriela Fernandez-Cuervo, Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Stephen Traynelis, Katie Strong, Rose Santangelo-Freel
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