Brominated Noscapine as a Potent Anti-Inflammatory
Key Benefits
Noscapine has been used safely in humans for over 30 years.
Noscapine analogs can inhibit inflammation in in vitro models.
Technical Summary
The innate immune system plays a crucial role in host defense and homeostasis. Innate immune responses are induced when pattern recognition receptors such as Toll-like receptors (TLR) sense...
Published: 11/6/2023
Contributor(s): Susu Zughaier, Ritu Aneja, David Stephens
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Targetin: New Targeted Non-Toxic Anti-Cancer Drug
Application
Compositions and methods for treating cancer and inflammatory disease using
noscapine and noscapine analogues conjugated to targeting molecules.
Key Benefits
Noscapine is a plant-derived alkaloid with a long-history of human use as
an anti-cough agent.
Noscapine is currently in phase I clinical trials for the treatment...
Published: 7/28/2023
Contributor(s): Harish Joshi, Suryan Vangapandu, Ritu Aneja
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Synthesizing Noscapine Analogues for Drug Resistance
Application Synthesis of noscapine analogs and their use as cancer treatments, including drug resistant cancers. Key BenefitsEfficient, high yielding synthesis of noscapine derivatives. Selective for cancer cells over normal human cells.Technical Summary The effectiveness of microtubule-targeting drugs as treatments for cancer has been validated through...
Published: 11/6/2023
Contributor(s): Harish Joshi, Ritu Aneja
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