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Compound and Method to Explore and Prepare O-Glycans from Living Cells
ApplicationChemical compound and method that enables detection of O-glycans with higher sensitivity than conventional approaches.Key BenefitsHigher accuracy and sensitivity than current β-elimination method.Smaller sample quantities required compared to traditional mass spectrometry.Method promotes the discovery of novel glycans and study of cellular...
Published: 3/1/2024       Contributor(s): Tongzhong Ju, Richard Cummings, Matthew Kudelka
P-selectin Inhibitor for the Treatment of Sickle Cell Disease
Application A glycopeptide inhibitor of p-selectin for the treatment of sickle cell disease. Key Benefits Blocks the activity of P-selectin with nM affinity. Potential treatment for vaso-occlusive crisis associated with sickle cell disease. Inhibits the earliest stage of leukocyte activation helping to prevent immune response. Market Summary Sickle...
Published: 4/8/2024       Contributor(s): Richard Cummings, Elliot Chaikof, Venkata Krishnamurthy, Mohammed Sardar
Antibiotic Protein Takes Aim at Blood Group B Pathogens
Application Antibiotic protein with the ability to target pathogens expressing the blood group B antigen. Key Benefits Naturally occurring factors produced by humans. Induces rapid cell death in bacteria expressing the blood group B antigen. Does not harm commensal bacteria. Technical Summary Emory University scientists have successfully...
Published: 3/11/2024       Contributor(s): Richard Cummings, Sean Stowell, Connie Arthur