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Theranostic Biomarker for Aspirin-Exacerbated Respiratory Disease
Application Biomarkers for a clinical diagnostic tool and non-psychogenic therapy to detect and treat aspirin-exacerbated respiratory disease. Key Benefits Does not rely on aspirin challenge, increasing safety and availability for suspected patients. May be used in patients who have respiratory compromise or are not stable. Minimally-invasiv...
Published: 7/2/2019       Inventor(s): Joshua Levy, Samuel Molina
Peptide Therapeutic for Acute Respiratory Distress Syndrome
ApplicationAnti-claudin 5 peptide to improve lung barrier function for the treatment of alcohol-induced acute respiratory distress syndrome (ARDS).Key BenefitsNew target for treating ARDS.Small inhibitory peptide to specifically target claudin-5.Market SummaryApproximately 200,000 cases of acute respiratory distress syndrome (ARDS) are diagnosed ea...
Published: 5/13/2019       Inventor(s): Michael Koval, Barbara Schlingmann-Molina
Alexidine and Analogs to Treat Lung Cancer
ApplicationSmall molecule therapeutic specifically targeting invasive cancer cells for treatment of lung cancer.Key BenefitsInhibits cancer cell invasion.Utilizes a novel mechanism of action.Market SummaryLung cancer is the second most prevalent type of cancer, causing more than 150,000 deaths in the United States per year. One of the main barriers...
Published: 4/12/2019       Inventor(s): Adam Marcus, Jessica Konen, Rachel Commander, Jamie Arnst, Thota Ganesh
Respiratory Syncytial Virus Strain A2-2-20F
ApplicationStrain of respiratory syncytial virus (RSV) for vaccine and therapeutic research and development.Key BenefitsHigher early viral load.Induces greater necrotic airway damage and neurophil infiltration.Market SummaryRSV is a highly contagious and ubiquitous virus that causes respiratory tract infections in individuals of all ages, particula...
Published: 10/16/2018       Inventor(s): Martin Moore
GeneRegs: Nanoparticles for Treatment of Severe Asthma
Application Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules. Key Benefits Specifically suppresses asthma associated inflammation. Easy self-administration by inhalation. Market Summary Asthma is defined as a chronic inflammatory lung disease with significant worldwide m...
Published: 12/4/2017       Inventor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior
Respiratory Syncytial Virus (RSV) A2 Expressing Firefly Luciferase
ApplicationRecombinant RSV strain expressing firefly luciferase and the F & G genes from clinical strain A2001/2-20 for research and development of vaccines.Key BenefitsF & G proteins included in this strain show different behavior than those of the typical A2 strain proteins.May be adapted in a variety of assays, enabling the identificatio...
Published: 2/19/2017       Inventor(s): Martin Moore, Christopher Stobart
Helper Plasmids for Rescue of Respiratory Syncytial Virus
ApplicationPlasmids rescuing recombinant syncytial virus for RSV research and vaccine development.Key BenefitsAllow expression and recombination in vero cells.Optimized for human codon bios to increase expression in mammalian cells.Market SummaryRespiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infections in infa...
Published: 2/16/2017       Inventor(s): Martin Moore
Plasmid for Respiratory Syncytial Virus (RSV) Vaccine Development & Research
ApplicationsBacterial artificial chromosome (BAC) plasmid containing the antigenomic sequence A2-BAG-BAF derived from multiple strains of RSV. Key BenefitsViral DNA is contained in a BAC, allowing for efficient mutagenesis and recombineering of viral DNA. BAC is stable and can be used for cloning in common bacteria types like E. coli.Provides power...
Published: 11/29/2016       Inventor(s): Martin Moore, Anne Hotard (Lopez-Ona)
Recombinant Respiratory Syncytial Virus (RSV) Firefly Luciferase Reporter Strain
ApplicationModified recombinant syncytial virus (RSV) strain expressing a bioluminescent reporter protein for high throughput screening and vaccine development.Key BenefitsProvides a new high throughput screening tool for RSV vaccine development and drug discovery.Firefly luciferase based assays show better signal-to-noise than fluorescence-based a...
Published: 11/14/2016       Inventor(s): Richard Plemper, Martin Moore
Recombinant RSV Strains Expressing Renilla Luciferase and G & F Proteins
Application Recombinant respiratory syncytial virus (RSV) strains expressing the G and F Proteins from RSV strains as well as renilla luciferase for use in drug and vaccine screening. Key Benefits Provides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, distinct strains of the virus....
Published: 1/19/2016       Inventor(s): Martin Moore, Jia Meng
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