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Using Antibodies to Inhibit Glycoprotein Ib-IX Mediated Platelet Signaling and Clearance for the Treatment of Thrombocytopenia
Application
A therapeutic agent to treat thrombocytopenia, the lack of sufficient platelets which can lead to excessive bleeding.
Key Benefits
This molecule modulates platelet signaling without blocking its ligand binding domain. Its mechanism of action targets a different part of the platelet life cycle from currently available therapeutics.
RAM.1...
Published: 11/27/2023
Contributor(s): Renhao Li, Francois Lanza, Wenchun Chen, Moriah Wilson
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Additives that Increase Storage and Shelf Life of Platelets
Application
Monoclonal antibody additive that inhibits ectodomain shedding of a platelet glycoprotein to improve platelet storage.
Key Benefits
Current storage techniques allows for limited storage times (5-7 days).
New additive may enable platelet storage at 4°C, increase platelet storage time, and improve quality of stored platelets.
Inhibits...
Published: 3/11/2024
Contributor(s): Renhao Li
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Scalable Linkage Formation Boosts Protein Engineering
Application
Efficient scalable method for creating peptide or amide linkages and generating peptides, proteins, or glycoproteins.
Key Benefits
Reactions involved are simple, mild, generalizable, and efficient, potentially reducing production costs.
Starting materials needed for this synthesis can also be produced easily and can be generated in...
Published: 12/7/2023
Contributor(s): Lanny Liebeskind, Wen-ting Wu, Zhihui Zhang, Hao Li, Angus Lamar
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