18 Results Sort by:
Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers. Key Benefits A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers. The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 3/1/2024       Contributor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
Automated Sleep Analysis Using Cardiovascular Signals
Application Sleep stage classification algorithm and diagnostic platform. Key Benefits Real-time sleep classification using a single electrocardiogram sensor. Eliminates the need for multiple head, eye, skin, and heart sensors with current diagnostics. Preliminary results using human data demonstrate high accuracy in identifying different sleep...
Published: 10/5/2023       Contributor(s): Gari Clifford, Shamim Nemati, Qiao Li, Supreeth Shashikumar
Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells
Application Machine learning tool to aid in the diagnosis of hematologic disorders of bone marrow. Key Benefits Automated machine learning-based approach for performing bone marrow differential counts that accounts for all viable cells on the smear. Data generated by a prototype shows the system is fast and demonstrates precision compared to manual...
Published: 11/27/2023       Contributor(s): Lee Cooper, David Gutman, David Jaye, Ahmed Aljudi, Ramraj Chandradevan
Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application Novel reagents for manufacturing of CAR T cells with improved characteristics. Key Benefits A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy. Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 1/10/2024       Contributor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
Liquid-hydrogel Hybrid Microfluidic Device
Application Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment. Key Benefits Fast determination of drug sensitivity. Long-term continuous cell-fate tracking. Time-lapse analysis of cell proliferation. Cell community analysis: intra-species interactions, inter-species interactions. Market...
Published: 11/27/2023       Contributor(s): Kyle Allison, Xin Fang, Devina Puri
Microfluidic and Organotypic Tumor Slice Culture Drug Testing Platform for Individualized Cancer Therapy
Application A drug combination screening/testing platform for individualized cancer therapy. Key Benefits Rapid screening of effective drug combination. Integrated tumor microenvironment. Identifying personalized therapy for individual cancer patient. Market Summary Traditional two-dimensional (2D) in vitro culture models for drug development...
Published: 1/25/2024       Contributor(s): Tobey John MacDonald, Anna Kenney, Abhinav Dey, YongTae (Tony) Kim
Using Mobile Location Data to Construct Large Social Networks
­ Application A software model for generating colocalization information from mobile data and constructing a social network. Key Benefits Software that can be licensed. Constructs social networks from any mobile location data. Largely reducing the total computational time by over 20 times. Scalable to extremely high data volumes. Market...
Published: 7/28/2023       Contributor(s): David Schweidel, Hanyu Zhang, Kunpeng Zhang
A New Method to Detect and Tackle Antibiotic Heteroresistance
­ Application A method to detect heteroresistance to antibiotics in bacteria. Key Benefits Significantly faster than commercially available options. Aside from the interferometer itself, no specialized reagents are required. Inexpensive to use. Market Summary Antibiotic resistance is a significant threat to public health. Rapid and sensitive...
Published: 3/1/2024       Contributor(s): David Weiss, Peter Yunker, David Hufnagel, Arben (Ben) Kalziqi
E-CARE: Resume Screening, Candidate Matching Software
Application Natural language processing (NLP) platform to facilitate more efficient, accurate, and non-biased identification of job candidates against open employment opportunities. Key Benefits Greatly reduces recruiter involvement. Provides superior applicant-to-job matching accuracy. Offers a plugin or API (Application Programming Interface)...
Published: 11/27/2023       Contributor(s): William Stephen (Steve) Pittard, Jinho Choi, Vicki Hertzberg, Elaine Fisher, Rebecca S. Thomas
Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein). Key Benefits Prevents the use of antibiotics and markers that promote resistance. Facilitates the deployment of recombinant bacteria in uncontrolled environments. Stabilizes heterologous expression of...
Published: 7/28/2023       Contributor(s): Ichiro Matsumura
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