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Liposome Encapsulated Tyrosine Kinase Inhibitors to Treat Leukemia
Application
Lipid encapsulation of MRX-2843 for the treatment of leukemia.
Key Benefits
Encapsulation of a tyrosine kinase inhibitor called MRX-2843 within a liposome improves its performance in an animal model of acute lymphoblastic leukemia.
Systemic delivery of this therapeutic requires a lower dose and less frequent administration than oral...
Published: 4/8/2024
Contributor(s): Erik Dreaden, James Kelvin, Deborah DeRyckere, Douglas Graham, Juhi Jain
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Questionnaires for Assessing the Effect of Visual Impairment on Quality of Life and Function in Children
Application
A standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents.
Key Benefits
Provides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults.
Allows the subjective assessment of the...
Published: 3/1/2024
Contributor(s): Sheila Angeles-Han
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Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application
A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers.
Key Benefits
A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers.
The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 3/1/2024
Contributor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
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RSV Vaccine for Infants and Children
Application
Vaccine for Respiratory Syncytial Virus (RSV) in infants and children.
Key Benefits
A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants.
Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease.
Potential to...
Published: 3/1/2024
Contributor(s): Larry Anderson, Binh Ha, Heying Sun
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Non-invasive Probes to Determine Efficacy of Cancer Therapies
Application
A real-time, non-invasive probe to determine the efficacy of cancer immunotherapies.
Key Benefits
Determines immunotherapy success in patients.
CAR cells can be tested before putting it back in the patients.
Simple diagnostic with readout in 30 minutes compared to 2-3 days.
Market Summary
Lymphoblastic leukemia is one of the most...
Published: 1/10/2024
Contributor(s): Anna Kellner, Khalid Salaita, Curtis Henry
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Choledocholithiasis (Gallstones in Bile) Prediction Algorithm iOS App
Application
A mobile app to predict gallstones in the bile duct in children.
Key Benefits
Accurate, non-invasive prediction of gallstones in the bile duct.
Based on readily available patient information.
Market Summary
Choledocholithiasis or bile stones in the gal duct is one of the most common medical conditions leading to surgical...
Published: 7/28/2023
Contributor(s): Reuven Zev Cohen, Alvin Freeman, Sheng Zhang
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Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA)
Application
Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy.
Key Benefits
A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen
The model can also be incorporated into future therapeutic...
Published: 7/28/2023
Contributor(s): William Hu, Sumit Verma
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Vision Test for Non-Verbal Children
Application
Vision testing for non-verbal children, the hearing impaired, and non English-speaking population.
Key Benefits
Simplifies vision testing for non-verbal children.
Does not require any verbal communication to be used effectively.
Technical Summary
While traditional eye charts are often effective, they rely on verbal communication...
Published: 7/28/2023
Contributor(s): Amy Hutchinson, Caroline Cromelin, Cindy Harrington
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3D Model for Analysis and Treatment Planning of Vascular Disease
Application
A patient-specific, 3D model of pulmonary atresia for surgical planning.
Key Benefits
Patient-specific model.
Allows for accurate surgical planning.
Enables new anastomosis procedure.
Market Summary
Pulmonary atresia (PA), ventricular septal defect (VSD) with major aortopulmonary collateral arteries (MAPCAs) is a rare congenital...
Published: 12/7/2023
Contributor(s): Vahid Serpooshan, Holly Bauser-Heaton, Martin Tomov
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Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application
Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients.
Key Benefits
Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 1/10/2024
Contributor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
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