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Organocatalysts for Amide Bond Formation
ApplicationChemically catalyzed amide bond formation under mild reaction conditions.Key BenefitsEnables amide bond formation under mild reaction conditions.Organocatalyst are easily synthesized.Avoids the use and disposal of hazardous chemicals.Market SummaryAmide bonds are very frequently incorporated into active pharmaceutical ingredients (API). Amide...
Published: 11/27/2023       Contributor(s): Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Sri Rama Murthy Akondi, Vidyavathi Patro, Nikolay Orlov
Small Molecule Potentiators of NMDA Receptors for Treating Neurological Conditions
Application Multiple series of small molecules that selectivity potentiate NMDA receptors composed of specific subunits including GluN2B, GluN2C, GluN2B/GluN2C/GluN2D, and GluN2C/GluN2D. Key Benefits Small molecule potentiators enhance endogenous signals without exogenous activation. Subunit selectivity allows targeting of specific subtypes of...
Published: 7/28/2023       Contributor(s): Dennis Liotta, Ethel Garnier-Amblard, Gabriela Fernandez-Cuervo, Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Stephen Traynelis, Katie Strong, Rose Santangelo-Freel