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CXCR4 Antagonists for the Treatment of Cancer
Application Small molecules containing either the piperidine or piperazine core which act as antagonists to C-X-C chemokine receptor type 4 (CXCR4) and may be orally administered. Key Benefits Orally administered CXCR4 antagonists with diverse clinical applications in oncology. Mobilize white blood cells in mice in a dose-dependent manner. Cause...
Published: 11/6/2023       Contributor(s): Lawrence (larry) Wilson, Dennis Liotta, John Wiseman, Michael Natchus
OSIRIS: An Information Management Application for Use in Drug Discovery and Development
Application A web-based information management application for data tracking and sharing during the discovery and development of new small molecule therapeutics. Key Benefits Can be used to register compounds and display information about chemical structures and calculations. Easily customizable and has a ticket system to allow administrators...
Published: 11/6/2023       Contributor(s): Serdar Kurtkaya, Iestyn Lewis, Michael Natchus, James Snyder
Synthetic Analogues of Progesterone
Application Therapeutic treatment of traumatic brain injury and other uses of progesterone where composition of matter intellectual property are required. Key Benefits 20 fold increase in solubility relative to the hormone progesterone. Synthetic analogues are as effective as progesterone in reducing cerebral edema following traumatic brain injury....
Published: 1/31/2024       Contributor(s): Dennis Liotta, Christopher Macnevin, Donald Stein, Michael Natchus, David Guthrie, Mark Lockwood, Iqbal Sayeed