CXCR4 Antagonists for the Treatment of Cancer
Application
Small molecules containing either the piperidine or piperazine core which act as antagonists to C-X-C chemokine receptor type 4 (CXCR4) and may be orally administered.
Key Benefits
Orally administered CXCR4 antagonists with diverse clinical applications in oncology.
Mobilize white blood cells in mice in a dose-dependent manner.
Cause...
Published: 11/6/2023
Contributor(s): Lawrence (larry) Wilson, Dennis Liotta, John Wiseman, Michael Natchus
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OSIRIS: An Information Management Application for Use in Drug Discovery and Development
Application
A web-based information management application for data tracking and sharing during the discovery and development of new small molecule therapeutics.
Key Benefits
Can be used to register compounds and display information about chemical structures and calculations.
Easily customizable and has a ticket system to allow administrators...
Published: 11/6/2023
Contributor(s): Serdar Kurtkaya, Iestyn Lewis, Michael Natchus, James Snyder
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Synthetic Analogues of Progesterone
Application
Therapeutic treatment of traumatic brain injury and other uses of progesterone where composition of matter intellectual property are required.
Key Benefits
20 fold increase in solubility relative to the hormone progesterone.
Synthetic analogues are as effective as progesterone in reducing cerebral edema following traumatic brain injury....
Published: 1/31/2024
Contributor(s): Dennis Liotta, Christopher Macnevin, Donald Stein, Michael Natchus, David Guthrie, Mark Lockwood, Iqbal Sayeed
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